
Dabigatran ethyl ester hydrochloride
CAS No. 211914-50-0
Dabigatran ethyl ester hydrochloride( —— )
Catalog No. M23966 CAS No. 211914-50-0
Dabigatran ethyl ester hydrochloride is an effective inhibitor of ribosyl dihydronicotinic acid amide dehydrogenase (NQO2) with an IC50 value of 0.8 μM and is a thrombin inhibitor.
Purity : >98% (HPLC)






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Biological Information
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Product NameDabigatran ethyl ester hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionDabigatran ethyl ester hydrochloride is an effective inhibitor of ribosyl dihydronicotinic acid amide dehydrogenase (NQO2) with an IC50 value of 0.8 μM and is a thrombin inhibitor.
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DescriptionDabigatran ethyl ester hydrochloride is an effective inhibitor of ribosyl dihydronicotinic acid amide dehydrogenase (NQO2) with an IC50 value of 0.8 μM and is a thrombin inhibitor.
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In VitroThe Ki of dabigatran (ethyl ester hydrochloride) toward NQO2 is 0.9 μM and the IC50 is 0.8 μM. The ethyl ester group of dabigatran (ethyl ester hydrochloride) significantly extends the interaction surface especially with hydrophobic amino acids such as Ile 128 and Met 154. Dabigatran ethyl ester has higher affinity than Dabigatran to both thrombin and NQO2. Dabigatran is a highly selective, reversible, and potent thrombin inhibitor and is orally available as the prodrug, dabigatran etexilate.
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In VivoDabigatran (Ki=4.5 nM) could bind to human thrombin selectively, and reversibly to realize a strong and long-lasting anticoagulant effect.
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Synonyms——
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PathwayAutophagy
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TargetThrombin
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Recptorthrombin|NQO2
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Research Area——
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Indication——
Chemical Information
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CAS Number211914-50-0
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Formula Weight536.03
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Molecular FormulaC27H30ClN7O3
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Purity>98% (HPLC)
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SolubilityDMSO:50 mg/mL (93.28 mM);H2O:5 mg/mL (9.33 mM; Need ultrasonic)
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SMILESCCOC(=O)CCN(C1=CC=CC=N1)C(=O)C2=CC3=C(C=C2)N(C(=N3)CNC4=CC=C(C=C4)C(=N)N)C.Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Michaelis S, et al. Dabigatran and dabigatran ethyl ester: potent inhibitors of ribosyldihydronicotinamide dehydrogenase (NQO2). J Med Chem. 2012 Apr 26;55(8):3934-44.
molnova catalog



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